{"id":1994,"date":"2021-08-19T22:20:13","date_gmt":"2021-08-19T20:20:13","guid":{"rendered":"https:\/\/parlonstechs.com\/all\/?p=1994"},"modified":"2021-08-19T22:21:52","modified_gmt":"2021-08-19T20:21:52","slug":"moderna-debute-les-essais-cliniques-de-son-vaccin-arnm-contre-le-vih","status":"publish","type":"post","link":"https:\/\/parlonstechs.com\/all\/2021\/08\/19\/moderna-debute-les-essais-cliniques-de-son-vaccin-arnm-contre-le-vih\/","title":{"rendered":"Moderna d\u00e9bute les essais cliniques de son vaccin ARNm contre le VIH"},"content":{"rendered":"\n
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L’entreprise de biotechnologie am\u00e9ricaine Moderna d\u00e9marre ainsi cette semaine ses essais cliniques pour tester un vaccin contre le VIH, le virus du sida.<\/strong><\/p>\n\n\n\n

Essai de phase 1 jusqu’en 2023<\/h2>\n\n\n\n

C’est le premier essai clinique men\u00e9 sur des humains pour ce vaccin. Une \u00e9tude dite de phase 1, sur un \u00e9chantillon restreint de patients, 56 personnes \u00e2g\u00e9es entre 18 et 50 ans non-infect\u00e9s et en bonnes conditions, indique la fiche de cet essai publi\u00e9e sur le site am\u00e9ricain officiel ClinicalTrials<\/a>.<\/p>\n\n\n\n

Le but de cette phase 1 est d’\u00e9valuer la s\u00e9curit\u00e9 du vaccin sous strict contr\u00f4le m\u00e9dical, notamment concernant ses potentiels effets secondaires, qu’il engendre bien une r\u00e9ponse immunitaire efficace avec la production d’anticorps mais aussi de d\u00e9finir la dose et la fr\u00e9quence d’administration qui seront recommand\u00e9es pour les \u00e9tudes suivantes. La phase 1 d\u00e9marre ce 19 ao\u00fbt et doit se terminer en avril 2023.<\/p>\n\n\n\n

Deux autres phases sont ensuite pr\u00e9vues avant la mise sur le march\u00e9 du vaccin.<\/p>\n\n\n\n

\u00ab\u00a0Malheureusement, hors d’un contexte de pand\u00e9mie, ces phases\u00a0prennent environ une dizaine d’ann\u00e9es… Mais l’\u00e9pid\u00e9mie de Covid-19 a prouv\u00e9 qu’on pouvait r\u00e9duire leur dur\u00e9e en cas de mobilisation mondiale et massive de la recherche ou s’il y a une urgence \u00e0 trouver un vaccin contre une maladie tr\u00e8s contagieuse, meurtri\u00e8re, et sans traitement\u00a0\u00bb, r\u00e9sumait\u00a0un article des\u00a0Derni\u00e8res nouvelles d’Alsace<\/em><\/a>\u00a0publi\u00e9 en avril dernier.<\/p>\n\n\n\n

Un article qui revenait d’ailleurs sur un autre essai, men\u00e9 par l’International AIDS Vaccine Initiative (IAVI) et l\u2019Institut de recherche Scripps, avec une r\u00e9ponse immunitaire record de 97% suite \u00e0 un essai sur 48 personnes (dont la moiti\u00e9 du panel qui avait re\u00e7u un placebo): \u00ab\u00a023 des 24 personnes qui ont re\u00e7u le vaccin, soit 97%, ont d\u00e9velopp\u00e9 une r\u00e9ponse immunitaire contre le VIH\u00a0\u00bb.<\/p>\n\n\n\n

Un \u00ab\u00a0co\u00fbt annuel du sida\u00a0\u00bb estim\u00e9 \u00e0 105 milliards de dollars<\/h2>\n\n\n\n

Moderna d\u00e9veloppe en parall\u00e8le d’autres vaccins ARNm, un deuxi\u00e8me contre le VIH, et d’autres comme le virus zika, comme l’indique une note disponible sur son site officiel<\/a> et mise \u00e0 jour le 5 ao\u00fbt dernier.<\/p>\n\n\n\n

Dans ce document, le laboratoire aborde le potentiel de ce vaccin, avec 38 millions de personnes dans le monde qui vivent avec le virus du sida, 2 millions de nouveaux malades chaque ann\u00e9e pour 690.000 qui en meurent.<\/p>\n\n\n\n

\u00ab\u00a0De 2010 \u00e0 2015, un total de 526,6 milliards de dollars a \u00e9t\u00e9 d\u00e9pens\u00e9 au niveau mondial pour soigner, traiter ou pr\u00e9venir le VIH, ce qui repr\u00e9sente un fardeau financier significatif\u00a0\u00bb, note Moderna. Un montant colosssal, qui repr\u00e9sente donc en moyenne sur la p\u00e9riode une d\u00e9pense annuelle de 105,32 milliards de dollars, environ 90 milliards d’euros.<\/p>\n\n\n\n

Il n’existe actuellement pas de vaccin approuv\u00e9 contre le VIH ou de traitement curatif efficace, note Moderna. Le vaccin viserait les jeunes adultes, avec un virus qui se transmet principalement via les rapports sexuels ou la consommation de drogues.<\/p>\n\n\n\n

Les scientifiques esp\u00e8rent une efficacit\u00e9 \u00e0 la hauteur de la protection apport\u00e9e par le vaccin contre le covid-19. L’ARN messager a l’avantage d’\u00eatre plus efficace contre les virus variants, un atout contre le VIH qui a mut\u00e9 plusieurs fois depuis sa d\u00e9couverte.<\/p>\n\n\n\n

BFMTV<\/p>\n","protected":false},"excerpt":{"rendered":"

L’entreprise de biotechnologie am\u00e9ricaine Moderna d\u00e9marre ainsi cette semaine ses essais cliniques pour tester un vaccin contre le VIH, le virus du sida. 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